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Fecal microbiota transplantation (FMT) further confirmed that the microbiota altered by heroin dependence was sufficient to impair body weight and intestinal mucosal barrier integrity in recipient mice. The gut microbial profiles in the mouse model with heroin dependence showed slightly decreased alpha diversity, as well as higher levels of Bifidobacterium and Sutterella and a decrease in Akkermansia at genus level compared to the control group. We show here that heroin addicts had a decrease in body mass index (BMI) and abnormal serum D-lactic acid (DLA), endotoxin (ET) and diamine oxidase (DAO) levels during their withdrawal stage, suggesting a potential intestinal injury. However, the underlying mechanism remains largely unknown.
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On Translational Activity (DaCCoTA) Clinical and Translational Research grants, theĭepartment of Pathology, and the UND School of Medicine & Health Sciences.The gut microbiota is believed to play a significant role in psychological and gastrointestinal symptoms in heroin addicts. TheīRCF is jointly supported by the North Dakota INBRE and the Dakota Cancer Collaborative Theįacility is conveniently located within the Center for Biomedical Research (CBR) andĭedicated for behavioral assessments, tissue collection and housing for mice. In addition to the infrastructure, the BRCF provides training and networking opportunitiesįor IDeA state investigators to interact and collaborate with other researchers. These systems are used for in vivo monitoring of electrophysiological activities as well as neurochemical modifications.Ī comprehensive list of our equipment is provided in BRCF’s regularly updated website, Populations with light or sleep deprivation. Of animal behavior resulting from precisely controlled activation of targeted neuronal Is equipped with a Pinnacle Optogenetics and Sleep-deprivation Systems for the analysis With the recent acquisition of multiple test devices, the BRCF isĬapable of assessing up to 6 animals simultaneously. Memory performance, and anxiety/depression-like behavior (San Diego Instruments and These devices include open-fieldĪctivity monitoring, grip strength, startle response, place preference, active/passiveĪvoidance, freeze monitoring, balance performance, rotational behavior, learning and
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ANY MAZE STOELTING SOFTWARE
Licensed analysis software (ANY-maze, Stoelting). The sensory-motorĪnd cognitive function assessment rooms are equipped with a variety of specializedĮquipment for assessment and monitoring of animal behavior, complete with multiple Laboratory, a procedure room, and a temporary animal holding room. Skills assessment room, a cognitive function assessment room, and a neurostimulation The new 5-room facility houses a sensory-motor In use, the BRCF has expanded to a newly renovated space as an annex of the Centerįor Biomedical Research (CBR) and hired a full-time Research Specialist for the operationĪnd management of the equipment and facility. State-of-the-art behavioral testing equipment 2) methodological and technical support ģ) training in behavioral testing and analysis and 4) interface for interactionsĪmong researchers to facilitate collaborations. Translational research in behavioral science by providing 1) well-managed and maintained The facility is designed to increase productivity in biomedical and The BRCF was established in 2015 to promote and strengthen behavioral research in About North Dakota Behavioral Research Core Facility (BRCF)